Difference Betwen Iago and Othello The main difference between Iago and Othello is that Iago was intelligent enough to use every characters he can to fulfill his revenge. He used everyone wisely; he even used Emilia and Desdemona although they are women. After Emilia had confronted Iago about his wicked plans by saying; “Disproved this villain, if thou be’st a man. He say thou toldst him that his wife was false. I know thou’rt not such a villain. Speak for my heart is full.” Iago replied; “ I told him what I thought and told no more than what he found himself was apt and true.” (Act V, sc.ii, lines179-184) Although Iago was solely responsible for the trage