Nutritional Protocol For Inflammation When tissues are injured a specific reaction to the injury takes place. A collection of irritants and other chemical mediators are released into the injured area to aid in stabilization of the injured tissue, protection against further injury, and stimulation of healing at the injury site. These factors are referred to as the inflammatory cascade. And it includes substances such as histamine, bradykinin and prostaglandins, which aid in vasodilation to the injured area; serotonin, which acts as a vasoconstrictor, and growth factors and cytokines which act to increase fibroblast and macrophag