In the early stages of the twentieth century, little was known about cell membranes. Until the early 1950s, the biological cell membrane was rarely mentioned in scientific literature. It was recognised that something was probably there, but hardly anything about it was known. Considering the lack of technical equipment available a century ago, scientists such as Charles Overton and Edwin Gorter were not only exploring new territory in looking at the properties of cell membranes, but laying the way for future cell biologists. Scientists had to wait another fifty years for the discovery of the electron microscope, let alone seventy years for the advent o