In the last 10 years, there has been some scientific leaps concerning diabetes, and genetic engineering. The increasing incidence and diagnostic detection of diabetes worldwide coupled with changing trends in the food animal market stimulated people to seek alternative sources of insulin completely independent of an animal-gland source. (Ryan, 1986). The basic recombinant DNA process of formulating insulin was developed. DNA carries the genetic information that determines the fate of each cell. Recombinant DNA technology allows manipulation of bacterial host cells by insertion of genes for production of either the A chain or the B chain of the insulin molecule, or the entire