Who Is The Villian In Macbeth? A villain is a person or character whom is the cause of despair and heartache for those who surround her. Villains are typically selfish towards themselves and careless towards others. A villain can be hypocritical, persuasive, mischievous, inhumane, and forceful. They can also lack a conscience. Even if they do have one, it is over burdened with their own guilt. The villain in Macbeth is Lady Macbeth, his wife. She is guilty because of the things that she does throughout the play. Lady Macbeth is most responsible for the tragic events in William Shakespeare