Lonliness in Of Mice and Men The novel Of Mice and Men by John Steinback deals with many themes that are reflective of the time period in which the novel was written. Loneliness is one of the many themes in this novel that are reflective of the time period in which the novel was written. It is shown in many of the characters in the novel. Loneliness is a theme in this novel that is reflective of the time period in which the novel was written. Loneliness haunts the characters in the novel Of Mice and Men. Nearly everyone in this book is a loner, and all are suspicious of George and Lennie’s companionship. Loneliness is said to cause peopl