Von Willebrand’s Disease Blood is carried throughout the body within a network of blood vessels. When our tissues are injured (cut on skin), are blood vessel is disrupted, and we bleed through the holes in the blood vessel wall. Normally, we stop bleeding through two integrated processes, or the formation of a platelet plug and the formation of a blood clot, this is called hemostasis. You may not know it, but there is a protein in or blood called the von Willebrand factor (vWF), which causes the platelets to bind to the bleeding blood vessel wall. These adherent platelets activate other platelets to clump at the hole on the blood vessel wall, this stops th