Hemophilia In the human body, each cell contains 46 chromosomes and 23 pairs of chromosomes, one of each pair is inherited through the egg from the mother, and the other inherited through the sperm of the father. Of these chromosomes, those that determine sex are X and Y. Females have XX and males have XY. In addition to the information on sex, the X chromosomes carry the main gene that holds the information for diseases. If a male holds the gene for hemophilia, then he automatically has the disease because he only has one x chromosome. Unlike males, females have two x chromosomes so if they have the heomphilia ge