The Black Plague The Black Plague was one of the worst and deadliest diseases known to man in the history of the world. The Plague originated in Italy and quickly spread throughout Europe killing more than one hundred thirty seven million people. Early treatments for the Plague were often bizarre but eventually came in a vaccine and through isolation. The symptoms of the Black Plague were swellings called buboes and dried blood under the skin that appeared black. The Black Plague changed the world in several different ways. It resulted in medical advances and architectural setbacks. In the 1300's one of the most fearful and deadliest diseases known to hum