Creatine Supplements and Athletes Creatine supplementation works. There have been over 100 studies done on creatine ingestion. The majority of the studies suggesting that creatine does enhance performance in athletics. It has been theorized that with increased muscle creatine content via creatine supplementation may allow for an accelerated rate of resynthesis of adenosine triphosphate (ATP). The accelerated resynthesis of ATP would allow individuals in athletic events that use the high intensity ATP-Pc energy system to perform longer. Short and long-term studies of creatine ingestion, has found one side effect; weight gain in fat free mass. Other theories of side effects ste