Of Mice and Men: Loneliness Question: The theme of loneliness is one that is all pervading in Of Mice and Men. Discuss this statement with references to both the novel and the film. The theme of loneliness features throughout many scenes in Of Mice and Men and is often the dominant theme of sections during this story. This theme occurs during many circumstances but is not present from start to finish. In my mind for a theme to be pervasive is must be present during every element of the story. There are many themes that are present most of the way through such as sacrifice, friendship and comradship. But in my opinion there is only one theme that is present from beginnin