A Comparison of the Medieval and Renaissance Eras It is amazing how significantly various aspects of society can and will change over a prolonged period of time. Between the time periods of the Medieval era and the Renaissance, one can note numerous significant changes, mainly those pertaining to art and religion. In general, ideals and subjects during the Renaissance became more secular. In Medieval times, people seemed to focus mainly on the church, God, and the afterlife; Whereas during the Renaissance, the focus was more secular: humans and life on earth. Although these two eras differ in many ways, the most concentrated differences deal with t