Flourescence In-situ Hybridisation and Its Advantages Flourescence in-situ hybridisation is a great advancement in technology because there are fewer chances of a miscarriage, the parents receive faster results, and the tests are easier to do. In the future, FISH will be able to decrease the chances of a miscarriage by using samples of maternal blood instead of amniotic fluid. The problem with amniocentesis is it uses a hollow needle to take fluid from the mother's uterus. The needle could damage the developing fetus if not inserted properly. Another advantage of FISH is that the parents get a much quicker test result than amnio