Drug Abuse Drug Abuse is generally defined as the use of a drug with such frequency that the user has physical or mental harm or it impairs social abilities. The substances that are discussed in this report are called psychoactive drugs; those drugs that influence or alter the workings of the mind, affect moods, emotions, feelings, and thinking processes. Drug Dependence/Addiction There are three basic characteristics that indicate that the user is dependent on a drug. First, the user continues to use the drug for an extended period of time. Second, the user finds it difficult to stop using the drug. They may dr