Loneliness and Friendship in Of Mice and Men I believe that loneliness and friendship is the most significant theme in John Steinbeck’s Of Mice and Men. I have many examples, which I will use to support my opinion. My first example is the two main characters from the book, George and Lennie. These two are completely different both physically and mentally, but because they are both alone they actually develop a friendship with each other. My next example is Candy, whom is an old janitor working on a ranch. Candy has an elderly dog that is in very poor shape, but since he has no friends on the ranch that dog became his best f