Reye Syndrome Reye Syndrome is an extremely rare, non-contagious disease thought to be triggered by aspirin use. The actual origin of the disease is unknown. Reye's Syndrome, occasionally called Reye-Jacobsen's Syndrome, is known to follow any viral infection. Two of the most common viral infections it precedes is influenza, “the flu”, and chicken pox. A now-familiar warning on bottles of aspirin, most notably Tylenol, is not to give Tylenol to a child who is recovering from the chicken pox, a fever, or any other viral infection. The link between aspirin and Reye's Syndrome and is not fully understood, but all reported cases of Reye's Syndrome include a child wh