Rome, Italy The City of Rome, Italy is located along the Tiber River in the west-central part of the Italian mainland, approximately a mere fifteen miles inland from the Tyrrhenian Sea. The City of Rome is situated on the famous Seven Hills of Rome, which are again bordered by hills to the north, south, and east. Rome originally rests on the Campagna, a coastal lowland built up from volcanic rocks. The hills are not very high averaging only one-hundred to two-hundred feet high and are covered by green plant life. Originally settlers migrated to this area because of the high elevations which were free of the disease