Uncle Tom's Cabin: Influence of the Setting The book, "Uncle Tom's Cabin" was obviously a novel where the setting was the major factor in the plot of the story. If this had taken place in any other area, like Canada, there would not have even been as story because slavery did not exist there. Therefore the South was the prime region to have this plot revolve around. Everything contained here contributed to the actions of the characters, which will be explained in the following paragraphs. The setting was such an important influence because, like I said before, it took place down in the South. This is wh