Seneca Indians: Allies and Enemies Seneca are among the most respected and feared. The Seneca are culturally similar to their Cayuga, Onondaga, Oneida, an Mohawk confederates. The five tribes were known as the Five Nations or the League of Five Nations. Sometime between 1715 and 1722 the Tuscaroras from North Carolina joined the confederacy and changed the name to the Six Nations. In their relations with white settlers the Seneca played the role of an independent power and were this way from the very start. During the colonial period they held the balance of power between the Fr